MayaUI: Do not restore saved layout from file
In preference, go to Interface/UI Elements/Panel Configurations and turn off the checkbox for "Restore saved layouts from file" in When opening.
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i3d: Prerequisites
# To find your Maya user script folder. def useScriptFolder(): import os; usd= cmds.internalVar(usd=True); usf= usd.rsplit('/', 3)[0]+"/scripts/"; if not os.path.exists(usf): usf= usd; return( usf ); print useScriptFolder(); # Files and Folders Locations